PEA belongs to the group of N- acylethanolamines which is naturally occurring and biologically active lipids that act on the cannabinoid receptor. The history of Palmitoylethanolamide is a natural food ingredient present in protein rich food. And was first found in the year 1943 as a part of an epidemiological study which is focused on rheumatic fever in the childhood period. Basically in those children who ate fewer eggs at that time and the investigators have observed that the occurrence of this was decreased in children egg yolk powder. The PEA works as an anti-inflammatory factor in egg yolks and found in the 1950s.
Types of Palmitoylethanolamide products you can find
- The formulation of Palmitoylethanolamide
This does not go well with water, the rate at which it dissolves in the stomach and intestine of your body. Which is then rate-limiting step for oral absorption as well as bioavailability. The formulation of PEA dissolves with particle size and it is micronized in order to dissolve in water quickly. The process of micronization helps to process the yield of different crystalline structures with increased energy content. And with smaller particles in the body which helps in better diffusion as well as the distribution of the molecules.
- Commercial products of PEA you will get
The Palmitoylethanolamide is marketed in the form of nutraceutical in human beings and it is also a constituent of cream for dry skin.
If you want to take PEA then it is recommended to take 300 to 600mg twice a day or a maximum up to 1200mg. The time period for any treatment has not been proved and many researchers have looked up to around three to four months.
Conditions which is treated by Palmitoylethanolamide and get the full benefit
- First is arthritis which is osteoarthritis and rheumatoid arthritis, as people who are suffering from this. And another is fibromyalgia in which people get more relief by using PEA.
- Peripheral neuropathies as diabetic neuropathy, chemotherapy, and sciatic pain.
- Many people who go for dental checkups also face dental pain and in that condition, PEA helps to reduce that.